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KMID : 0383820150780020092
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Tuberculosis and Respiratory Diseases
2015 Volume.78 No. 2 p.92 ~ p.98
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Seven-Day Continuous Abstinence Rate from Smoking at 1, 2, or 3 Years after the Use of Varenicline
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Kim Jin-Se
Jang Ju-Young
Park Eun-Hye
Lee Joo-Young
Gu Kang-Mo
Jung Jae-Woo
Choi Jae-Chol
Shin Jong-Wook
Park In-Won
Choi Byoung-Whui
Kim Jae-Yeol
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Abstract
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Background : Varenicline, a selective partial agonist/antagonist of the α4β2 nicotinic receptor, has proven effectiveness for smoking cessation by several randomized, controlled trials. Because few studies have evaluated the long-term efficacy of varenicline, we tried to evaluate the smoking status of varenicline users up to 3 years after the initial prescription of the drug.
Materials and Methods : We interviewed varenicline users who were prescribed the drug from June 2007 to May 2010 by telephone, from June 2010 to May 2011.
Results : One-hundred and thirty-three of 250 varenicline users (53.2%) were available for the survey. Seven-day continuous abstinence from smoking was adhered to by 17 of 39 respondents (43.6%) at 1 year, and 11 of 36 (30.6%) and 19 of 58 (32.8%) at 2 and 3 years since the first use of varenicline, respectively. Compared to current smokers, successful quitters were older (55.0 years vs. 49.9 years, p=0.01), had better compliance to the 12-week course (27.7 vs. 9.3%, p=0.01), and had taken varenicline longer (10.1 vs. 5.9 weeks, p=0.01). Fifty-four of 71 current smokers (76.1%) were willing to stop smoking in the near future. The preferred ways to cease smoking were will-power (48.1%), varenicline (25.9%), nicotine replacement therapy (11.1%), and others (14.9%).
Conclusion : Smokers should be encouraged to stick to the proven way for recommended period of time for successful cessation of smoking.
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KEYWORD
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Compliance, Smoking, Varenicline
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